MST1R 抗体 (AA 1175-1400)
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- 抗原 See all MST1R 抗体
- MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))
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抗原表位
- AA 1175-1400
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MST1R antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Macrophage-stimulating protein receptor protein (1175-1400AA)
- 亚型
- IgG
- Top Product
- Discover our top product MST1R Primary Antibody
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- 应用备注
- Recommended dilution: IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))
- 别名
- MST1R (MST1R 产品)
- 别名
- CD136 antibody, CDw136 antibody, PTK8 antibody, RON antibody, Fv-2 antibody, Fv2 antibody, Ron antibody, STK antibody, Cdw136 antibody, Ptk8 antibody, Stk antibody, macrophage stimulating 1 receptor antibody, macrophage stimulating 1 receptor (c-met-related tyrosine kinase) antibody, MST1R antibody, Mst1r antibody
- 背景
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Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Aliases: c met related tyrosine kinase antibody, CD136 antibody, CD136 antigen antibody, CDw136 antibody, Macrophage stimulating 1 receptor (c met related tyrosine kinase) antibody, Macrophage stimulating 1 receptor antibody, Macrophage stimulating protein receptor alpha chain antibody, MACROPHAGE STIMULATING PROTEIN RECEPTOR antibody, Macrophage stimulating protein receptor beta chain antibody, Macrophage-Stimulating 1 Receptor (MST1R) antibody, Macrophage-stimulating protein receptor beta chain antibody, MSP receptor antibody, Mst1r antibody, MST1R variant RON30 antibody, MST1R variant RON62 antibody, NPCA3 antibody, p185 RON antibody, p185-Ron antibody, Protein-tyrosine kinase 8 antibody, PTK 8 antibody, ptk8 antibody, PTK8 protein tyrosine kinase 8 antibody, Recepteur drigine nantais (RON) antibody, RON antibody, RON protein tyrosine kinase antibody, RON variant E2E3 antibody, RON_HUMAN antibody, Soluble RON variant 1 antibody, Soluble RON variant 2 antibody, Soluble RON variant 3 antibody, Soluble RON variant 4 antibody, Stem cell derived tyrosine kinase antibody
- UniProt
- Q04912
- 途径
- RTK signaling
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