LAPTM4B 抗体 (AA 174-226) (HRP)
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- 抗原 See all LAPTM4B 抗体
- LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))
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抗原表位
- AA 174-226
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LAPTM4B antibody is conjugated to HRP
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应用范围
- ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Lysosomal-associated transmembrane protein 4B protein (174-226AA)
- 亚型
- IgG
- Top Product
- Discover our top product LAPTM4B Primary Antibody
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anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 174-226) antibody
LAPTM4B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 195-209) antibodyLAPTM4B 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB42294 unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (Internal Region) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (Middle Region) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 兔, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 216-265) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 218-317) antibodyLAPTM4B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))
- 别名
- LAPTM4B (LAPTM4B 产品)
- 别名
- LAPTM4beta antibody, LC27 antibody, C330023P13Rik antibody, lysosomal protein transmembrane 4 beta antibody, lysosomal-associated protein transmembrane 4B antibody, LAPTM4B antibody, Laptm4b antibody
- 背景
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Background: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).
Aliases: LAPTM4B antibody, PSEC0001 antibody, Lysosomal-associated transmembrane protein 4B antibody, Lysosome-associated transmembrane protein 4-beta antibody
- UniProt
- Q86VI4
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