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LSD1 抗体 (AA 100-150)

KDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7158724
发货至: 中国
  • 抗原 See all LSD1 (KDM1A) 抗体
    LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
    抗原表位
    • 15
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
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    AA 100-150
    适用
    • 74
    • 36
    • 30
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    宿主
    • 57
    • 15
    • 1
    克隆类型
    • 57
    • 17
    多克隆
    标记
    • 54
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This LSD1 antibody is un-conjugated
    应用范围
    • 66
    • 33
    • 24
    • 20
    • 17
    • 13
    • 13
    • 10
    • 5
    • 4
    • 3
    • 3
    • 3
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    人, 小鼠
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Lysine-specific histone demethylase 1A protein (100-150AA)
    亚型
    IgG
    Top Product
    Discover our top product KDM1A Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
    别名
    KDM1A (KDM1A 产品)
    背景

    Background: Histone demethylase that demethylates both \\\'Lys-4\\\' (H3K4me) and \\\'Lys-9\\\' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of \\\'Thr-6\\\' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated \\\'Lys-370\\\' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.

    Aliases: Amine oxidase (flavin containing) domain 2 antibody, Amine oxidase, flavin containing, 2 antibody, AOF2 antibody, BHC110 antibody, BRAF35 HDAC complex protein BHC110 antibody, BRAF35-HDAC complex protein BHC110 antibody, BRAF35/HDAC complex, 110-kD subunit antibody, CPRF antibody, EC1 antibody, FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody, Flavin-containing amine oxidase domain-containing protein 2 antibody, KDM 1 antibody, KDM1 antibody, Kdm1a antibody, KDM1A_HUMAN antibody, KIAA0601 antibody, LSD 1 antibody, LSD1 antibody, Lysine (K) specific demethylase 1 antibody, Lysine (K) specific demethylase 1A antibody, Lysine demethylase 1A antibody, Lysine specific histone demethylase 1 antibody, Lysine specific histone demethylase 1A antibody, Lysine-specific demethylase 1 antibody, Lysine-specific demethylase 1A antibody, Lysine-specific histone demethylase 1A antibody

    UniProt
    O60341
    途径
    Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect
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