LRP4 抗体 (AA 1500-1725)
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- 抗原 See all LRP4 抗体
- LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))
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抗原表位
- AA 1500-1725
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LRP4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Low-density lipoprotein receptor-related protein 4 protein (1500-1725AA)
- 亚型
- IgG
- Top Product
- Discover our top product LRP4 Primary Antibody
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- 应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))
- 别名
- LRP4 (LRP4 产品)
- 别名
- CLSS antibody, LRP-4 antibody, LRP10 antibody, MEGF7 antibody, SOST2 antibody, Megf7 antibody, 6430526J12Rik antibody, D230026E03 antibody, mdig antibody, LRP4 antibody, lrp10 antibody, megf7 antibody, LDL receptor related protein 4 antibody, low density lipoprotein receptor-related protein 4 antibody, LRP4 antibody, Lrp4 antibody, lrp4 antibody
- 背景
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Background: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.
Aliases: KIAA0816 antibody, LDLR dan antibody, Low density lipoprotein receptor related protein 4 antibody, Low-density lipoprotein receptor-related protein 4 antibody, LRP-4 antibody, LRP10 antibody, Lrp4 antibody, LRP4_HUMAN antibody, MEGF7 antibody, Multiple epidermal growth factor like domains 7 antibody, Multiple epidermal growth factor-like domains 7 antibody
- UniProt
- O75096
- 途径
- Skeletal Muscle Fiber Development
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