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- 抗原 See all LAIR1 抗体
- LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))
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抗原表位
- AA 22-165
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LAIR1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 protein (22-165AA)
- 亚型
- IgG
- Top Product
- Discover our top product LAIR1 Primary Antibody
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anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) antibody
LAIR1 适用: 人 WB, FACS, IP 宿主: 小鼠 Monoclonal NKTA255 unconjugated
anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 22-165) antibodyLAIR1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1G8B6 unconjugated
anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 1-287) antibodyLAIR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 1-287) antibodyLAIR1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3B2 unconjugated
anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 188-287) antibodyLAIR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G4 unconjugated
anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) antibody (APC)LAIR1 适用: 人 FACS 宿主: 小鼠 Monoclonal NKTA255 APC
anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (Internal Region) antibodyLAIR1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (Internal Region) antibodyVerified LAIR1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) antibody (PE)LAIR1 适用: 人 FACS 宿主: 小鼠 Monoclonal NKTA255 PE
anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 40-208) antibodyLAIR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))
- 别名
- LAIR1 (LAIR1 产品)
- 别名
- 5133400O11Rik antibody, BB115266 antibody, D7Bwg0421e antibody, Lair-1 antibody, mLair-1 antibody, CD305 antibody, LAIR-1 antibody, leukocyte-associated Ig-like receptor 1 antibody, leukocyte associated immunoglobulin like receptor 1 antibody, leukocyte-associated immunoglobulin-like receptor 1 antibody, Lair1 antibody, LAIR1 antibody
- 背景
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Background: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Aliases: 5133400O11Rik antibody, CD305 antibody, D7Bwg0421e antibody, hLAIR1 antibody, LAIR 1 antibody, LAIR-1 antibody, LAIR1 antibody, LAIR1 protein antibody, LAIR1_HUMAN antibody, Leukocyte associated Ig like receptor 1 antibody, Leukocyte associated immunoglobulin like receptor 1 antibody, Leukocyte-associated immunoglobulin-like receptor 1 antibody
- UniProt
- Q6GTX8
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