KEAP1 抗体 (AA 1-624)
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- 抗原 See all KEAP1 抗体
- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
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抗原表位
- AA 1-624
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KEAP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人, 小鼠
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Kelch-like ECH-associated protein 1 protein (1-624AA)
- 亚型
- IgG
- Top Product
- Discover our top product KEAP1 Primary Antibody
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
- 别名
- KEAP1 (KEAP1 产品)
- 别名
- INrf2 antibody, KLHL19 antibody, INRF2 antibody, mKIAA0132 antibody, Inrf2 antibody, fb36f11 antibody, keap1 antibody, wu:fb36f11 antibody, KEAP1 antibody, klhl19 antibody, zgc:171654 antibody, kelch like ECH associated protein 1 antibody, kelch-like ECH-associated protein 1 antibody, Kelch-like ECH-associated protein 1 antibody, kelch-like ECH-associated protein 1a antibody, kelch like ECH associated protein 1 L homeolog antibody, kelch-like ECH-associated protein 1b antibody, KEAP1 antibody, Keap1 antibody, keap1a antibody, keap1 antibody, keap1.L antibody, keap1b antibody
- 背景
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Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Aliases: Cytosolic inhibitor of Nrf2 antibody, INrf 2 antibody, INrf2 antibody, Keap 1 antibody, KEAP1 antibody, KEAP1_HUMAN antibody, Kelch like ECH associated protein 1 antibody, Kelch like family member 19 antibody, Kelch like protein 19 antibody, Kelch-like ECH-associated protein 1 antibody, Kelch-like protein 19 antibody, KIAA0132 antibody, KLHL 19 antibody, KLHL19 antibody, MGC10630 antibody, MGC1114 antibody, MGC20887 antibody, MGC4407 antibody, MGC9454 antibody
- UniProt
- Q14145
- 途径
- Maintenance of Protein Location
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