KPNA1 抗体 (AA 8-538)
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- 抗原 See all KPNA1 抗体
- KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))
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抗原表位
- AA 8-538
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KPNA1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Importin subunit alpha-5 protein (8-538AA)
- 亚型
- IgG
- Top Product
- Discover our top product KPNA1 Primary Antibody
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))
- 别名
- KPNA1 (KPNA1 产品)
- 别名
- IPOA5 antibody, NPI-1 antibody, RCH2 antibody, SRP1 antibody, AW494490 antibody, NPI1 antibody, Rch2 antibody, mSRP1 antibody, si:ch211-161h7.7 antibody, karyopherin subunit alpha 1 antibody, importin alpha-1 subunit antibody, karyopherin (importin) alpha 1 antibody, karyopherin alpha 1 (importin alpha 5) antibody, KPNA1 antibody, Kpna1 antibody, EHI_124900 antibody, kpna1 antibody
- 背景
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Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Aliases: IMA5_HUMAN antibody, Importin alpha 1 subunit antibody, Importin alpha 5 antibody, Importin alpha S1 antibody, Importin subunit alpha-5, N-terminally processed antibody, IPO A5 antibody, IPOA 5 antibody, IPOA5 antibody, Karyopherin alpha 1 antibody, Karyopherin alpha 1 subunit antibody, Karyopherin subunit alpha-1 antibody, KPNA 1 antibody, KPNA1 antibody, mSRP 1 antibody, mSRP1 antibody, NPI 1 antibody, NPI-1 antibody, NPI1 antibody, Nucleoprotein interactor 1 antibody, RAG cohort protein 2 antibody, RCH 2 antibody, RCH2 antibody, Recombination activating gene cohort 2 antibody, SRP 1 antibody, SRP1 beta antibody, SRP1-beta antibody
- UniProt
- P52294
- 途径
- M Phase, Protein targeting to Nucleus
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