IgD 抗体 (AA 1-240)
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- 抗原 See all IgD 抗体
- IgD
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抗原表位
- AA 1-240
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IgD antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人, 小鼠
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Ig delta chain C region protein (1-240AA)
- 亚型
- IgG
- Top Product
- Discover our top product IgD Primary Antibody
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- 应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- IgD
- 别名
- IGHD (IgD 产品)
- 别名
- IgD antibody, Igh-5 antibody, immunoglobulin heavy constant delta antibody, immunoglobulin delta heavy chain constant region antibody, Ighd antibody, Igd antibody, IGHD antibody
- 物质类
- Antibody
- 背景
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Background: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
Aliases: IGHD antibody, Immunoglobulin heavy constant delta antibody, Ig delta chain C region antibody, Ig delta chain C region NIG-65 antibody, Ig delta chain C region WAH antibody
- UniProt
- P01880
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