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- 抗原 See all HIC1 抗体
- HIC1 (Hypermethylated in Cancer 1 (HIC1))
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抗原表位
- AA 297-418
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HIC1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Hypermethylated in cancer 1 protein (297-418AA)
- 亚型
- IgG
- Top Product
- Discover our top product HIC1 Primary Antibody
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anti-Hypermethylated in Cancer 1 (HIC1) (AA 396-453) antibody
HIC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E11 unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 396-453) antibodyHIC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E11 unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 193-204) antibodyVerified HIC1 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) antibodyHIC1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 627-705) antibodyHIC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F2 unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 209-258) antibodyHIC1 适用: 人, 小鼠, 大鼠, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 215-264) antibodyHIC1 适用: 人, 小鼠, 大鼠, 犬, Cow, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 899-948) antibodyHIC1 适用: 人, 豚鼠, 犬, Cow, Pig, 猴, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 180-430) antibodyHIC1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:200-1:500,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- HIC1 (Hypermethylated in Cancer 1 (HIC1))
- 别名
- HIC1 (HIC1 产品)
- 别名
- zfHIC1 antibody, HIC1 antibody, ZBTB29 antibody, ZNF901 antibody, hic-1 antibody, AA408311 antibody, HIC-1 antibody, hypermethylated in cancer 1 antibody, HIC ZBTB transcriptional repressor 1 antibody, hic1 antibody, HIC1 antibody, Hic1 antibody
- 背景
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Background: Transcriptional repressor. Recognizes and binds to the consensus sequence \\\'5-[CG]NG[CG]GGGCA[CA]CC-3\\\'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
Aliases: Hic 1 antibody, HIC ZBTB transcriptional repressor 1 antibody, Hic-1 antibody, Hic1 antibody, HIC1_HUMAN antibody, Hypermethylated in cancer 1 antibody, Hypermethylated in cancer 1 protein antibody, ZBTB29 antibody, Zinc finger and BTB domain-containing protein 29 antibody, ZNF901 antibody
- UniProt
- Q14526
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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