GNA12 抗体 (AA 112-270)
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- 抗原 See all GNA12 抗体
- GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
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抗原表位
- AA 112-270
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GNA12 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA)
- 亚型
- IgG
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anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (AA 301-381) antibody
GNA12 适用: 人 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (C-Term) antibodyGNA12 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Internal Region) antibodyVerified GNA12 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (AA 146-195) antibodyGNA12 适用: 人, 大鼠, 小鼠, 犬, 兔, 豚鼠, 马, Cow, 斑马鱼, 猴, Pig, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Ser67) antibodyGNA12 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (AA 1-200) antibodyGNA12 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Middle Region) antibodyGNA12 适用: 人, 大鼠, 小鼠, 犬, 兔, 豚鼠, 马, Cow, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
- 别名
- GNA12 (GNA12 产品)
- 别名
- NNX3 antibody, RMP antibody, gep antibody, gna12 antibody, gna12l antibody, AI414047 antibody, AI504261 antibody, Galpha12 antibody, G protein subunit alpha 12 antibody, guanine nucleotide binding protein (G protein) alpha 12a antibody, guanine nucleotide binding protein, alpha 12 antibody, GNA12 antibody, Gna12 antibody, gna12a antibody
- 背景
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Background: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
Aliases: G alpha 12 antibody, G alpha-12 antibody, G-protein subunit alpha-12 antibody, gep antibody, Gna12 antibody, GNA12_HUMAN antibody, guanine nucleotide binding protein (G protein) alpha 12 antibody, Guanine nucleotide binding protein alpha 12 subunit antibody, Guanine nucleotide-binding protein subunit alpha-12 antibody, MGC104623 antibody, MGC99644 antibody, NNX3 antibody, RMP antibody, WUGSC:H_GS165O14.2 antibody
- UniProt
- Q03113
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