GRHL2 抗体 (AA 1-265) (Biotin)
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- 抗原 See all GRHL2 抗体
- GRHL2 (Grainyhead-Like 2 (GRHL2))
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抗原表位
- AA 1-265
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GRHL2 antibody is conjugated to Biotin
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应用范围
- ELISA
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Grainyhead-like protein 2 homolog protein (1-265AA)
- 亚型
- IgG
- Top Product
- Discover our top product GRHL2 Primary Antibody
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anti-Grainyhead-Like 2 (GRHL2) (AA 1-625) antibody
GRHL2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Grainyhead-Like 2 (GRHL2) (AA 1-265) antibodyGRHL2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Grainyhead-Like 2 (GRHL2) (C-Term) antibodyGRHL2 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 斑马鱼, 豚鼠, 马, 小鸡, 非洲爪蟾, Bat, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Grainyhead-Like 2 (GRHL2) (Middle Region) antibodyGRHL2 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 斑马鱼, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Grainyhead-Like 2 (GRHL2) (AA 111-210) antibodyGRHL2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Grainyhead-Like 2 (GRHL2) (AA 80-250) antibodyGRHL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Grainyhead-Like 2 (GRHL2) (Middle Region) antibodyGRHL2 适用: 人, 小鼠, 大鼠, Cow, 犬, 斑马鱼, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- GRHL2 (Grainyhead-Like 2 (GRHL2))
- 别名
- GRHL2 (GRHL2 产品)
- 别名
- grhl2 antibody, si:dkey-21k18.2 antibody, GRHL2 antibody, BOM antibody, DFNA28 antibody, TFCP2L3 antibody, RGD1561191 antibody, 0610015A08Rik antibody, Tcfcp2l3 antibody, zgc:110324 antibody, grainyhead-like transcription factor 2b antibody, grainyhead like transcription factor 2 antibody, grainyhead-like transcription factor 2 antibody, grainyhead-like 2 (Drosophila) antibody, grainyhead-like transcription factor 2a antibody, grhl2b antibody, GRHL2 antibody, Grhl2 antibody, grhl2a antibody
- 背景
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Background: Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456). Binds directly to the consensus DNA sequence 5\\\'-AACCGGTT-3\\\' acting as an activator and repressor on distinct target genes. During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions. Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair. In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation. In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5\\\'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293).
Aliases: BOM antibody, Brother of mammalian grainyhead antibody, Deafness autosomal dominant 28 antibody, DFNA28 antibody, ECTDS antibody, FLJ11172 antibody, FLJ13782 antibody, Grainyhead like 2 (Drosophila) antibody, Grainyhead like 2 antibody, Grainyhead like protein 2 homolog antibody, Grainyhead like transcription factor 2 antibody, Grainyhead-like protein 2 homolog antibody, GRHL 2 antibody, GRHL2 antibody, GRHL2_HUMAN antibody, MGC149294 antibody, MGC149295 antibody, RGD1561191 antibody, TFCP2L3 antibody, Transcription factor CP2 like 3 antibody, Transcription factor CP2-like 3 antibody
- UniProt
- Q6ISB3
- 途径
- Tube Formation
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