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Fibrillin 1 抗体 (AA 783-850)

FBN1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7152751
发货至: 中国
  • 抗原 See all Fibrillin 1 (FBN1) 抗体
    Fibrillin 1 (FBN1)
    抗原表位
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 783-850
    适用
    • 64
    • 31
    • 22
    • 11
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    宿主
    • 75
    • 12
    • 1
    克隆类型
    • 77
    • 11
    多克隆
    标记
    • 42
    • 16
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Fibrillin 1 antibody is un-conjugated
    应用范围
    • 57
    • 29
    • 29
    • 15
    • 14
    • 13
    • 13
    • 13
    • 12
    • 9
    • 5
    • 3
    • 2
    • 1
    Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Fibrillin-1 protein (783-850AA)
    亚型
    IgG
    Top Product
    Discover our top product FBN1 Primary Antibody
  • 应用备注
    Recommended dilution: IHC:1:20-1:200, IF:1:200-1:500,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    Fibrillin 1 (FBN1)
    别名
    FBN1 (FBN1 产品)
    背景

    Background: Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca2+ signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921).

    Aliases: 350 kDa glycoprotein component extracellular microfibril antibody, ACMICD antibody, FBN 1 antibody, FBN antibody, FBN1 antibody, FBN1_HUMAN antibody, Fibrillin 15 antibody, Fibrillin-1 antibody, Fibrillin1 antibody, Fibrillin15 antibody, GPHYSD2 antibody, Marfan syndrome antibody, MASS antibody, MFS 1 antibody, MFS1 antibody, OCTD antibody, SGS antibody, SSKS antibody, Weill Marchesani syndrome antibody, WMS antibody, WMS2 antibody

    UniProt
    P35555
    途径
    Maintenance of Protein Location, SARS-CoV-2 Protein Interactome
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