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FAN1 抗体 (AA 167-373) (Biotin)

FAN1 适用: 人 ELISA 宿主: 兔 Polyclonal Biotin
产品编号 ABIN7152567
发货至: 中国
  • 抗原 See all FAN1 抗体
    FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))
    抗原表位
    • 7
    • 3
    • 2
    • 2
    • 1
    AA 167-373
    适用
    • 22
    • 1
    宿主
    • 20
    • 2
    克隆类型
    • 22
    多克隆
    标记
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FAN1 antibody is conjugated to Biotin
    应用范围
    • 11
    • 10
    • 7
    • 3
    • 3
    • 1
    • 1
    • 1
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Fanconi-associated nuclease 1 protein (167-373AA)
    亚型
    IgG
    Top Product
    Discover our top product FAN1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))
    别名
    FAN1 (FAN1 产品)
    别名
    KIAA1018 antibody, KMIN antibody, MTMR15 antibody, 6030441H18Rik antibody, Mtmr15 antibody, fi39f01 antibody, mtmr15 antibody, si:ch211-163b1.2 antibody, si:ch211-201b11.2 antibody, wu:fd06a07 antibody, wu:fi39f01 antibody, RGD1566323 antibody, FANCD2 and FANCI associated nuclease 1 antibody, FANCD2/FANCI-associated nuclease 1 antibody, FAN1 antibody, Fan1 antibody, fan1 antibody
    背景

    Background: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5\'-3\' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3\'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5\'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3\' flap (PubMed:25430771). Also has endonuclease activity toward 5\'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).

    Aliases: 6030441H18Rik antibody, Coiled coil domain containing protein MTMR15 antibody, DKFZp451H236 antibody, DKFZp686K16147 antibody, FAN1 antibody, FAN1_HUMAN antibody, FANCD2 and FANCI associated nuclease 1 antibody, FANCD2/FANCI associated nuclease 1 antibody, FANCD2/FANCI-associated nuclease 1 antibody, Fanconi associated nuclease 1 antibody, Fanconi-associated nuclease 1 antibody, hFAN1 antibody, KIAA1018 antibody, KMIN antibody, MTMR 15 antibody, MTMR15 antibody, Myotubularin related protein 15 antibody, Myotubularin-related protein 15 antibody

    UniProt
    Q9Y2M0
    途径
    DNA Damage Repair
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