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- 抗原 See all FAN1 抗体
- FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))
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抗原表位
- AA 167-373
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FAN1 antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Fanconi-associated nuclease 1 protein (167-373AA)
- 亚型
- IgG
- Top Product
- Discover our top product FAN1 Primary Antibody
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anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 1-533) antibody
FAN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) antibodyFAN1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 146-174), (N-Term) antibodyFAN1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB26526 unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))
- 别名
- FAN1 (FAN1 产品)
- 别名
- KIAA1018 antibody, KMIN antibody, MTMR15 antibody, 6030441H18Rik antibody, Mtmr15 antibody, fi39f01 antibody, mtmr15 antibody, si:ch211-163b1.2 antibody, si:ch211-201b11.2 antibody, wu:fd06a07 antibody, wu:fi39f01 antibody, RGD1566323 antibody, FANCD2 and FANCI associated nuclease 1 antibody, FANCD2/FANCI-associated nuclease 1 antibody, FAN1 antibody, Fan1 antibody, fan1 antibody
- 背景
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Background: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5\\\'-3\\\' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3\\\'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5\\\'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3\\\' flap (PubMed:25430771). Also has endonuclease activity toward 5\\\'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).
Aliases: 6030441H18Rik antibody, Coiled coil domain containing protein MTMR15 antibody, DKFZp451H236 antibody, DKFZp686K16147 antibody, FAN1 antibody, FAN1_HUMAN antibody, FANCD2 and FANCI associated nuclease 1 antibody, FANCD2/FANCI associated nuclease 1 antibody, FANCD2/FANCI-associated nuclease 1 antibody, Fanconi associated nuclease 1 antibody, Fanconi-associated nuclease 1 antibody, hFAN1 antibody, KIAA1018 antibody, KMIN antibody, MTMR 15 antibody, MTMR15 antibody, Myotubularin related protein 15 antibody, Myotubularin-related protein 15 antibody
- UniProt
- Q9Y2M0
- 途径
- DNA Damage Repair
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