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XPO1 抗体 (AA 625-845)

XPO1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7152317
发货至: 中国
  • 抗原 See all XPO1 抗体
    XPO1 (Exportin 1 (XPO1))
    抗原表位
    • 15
    • 11
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 625-845
    适用
    • 73
    • 36
    • 35
    • 8
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 68
    • 5
    克隆类型
    • 57
    • 16
    多克隆
    标记
    • 40
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This XPO1 antibody is un-conjugated
    应用范围
    • 45
    • 17
    • 15
    • 14
    • 14
    • 14
    • 8
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    人, 小鼠
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Exportin-1 protein (625-845AA)
    亚型
    IgG
    Top Product
    Discover our top product XPO1 Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    XPO1 (Exportin 1 (XPO1))
    别名
    XPO1 (XPO1 产品)
    背景

    Background: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

    Aliases: Chromosome region maintenance 1 protein homolog antibody, CRM 1 antibody, CRM1 homolog antibody, DKFZp686B1823 antibody, emb antibody, Exp 1 antibody, Exp1 antibody, Exportin 1 antibody, Exportin-1 antibody, Exportin1 antibody, XPO 1 antibody, xpo1 antibody, XPO1_HUMAN antibody

    UniProt
    O14980
    途径
    M Phase
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