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EXOSC1 抗体 (AA 9-195) (Biotin)

EXOSC1 适用: 人 ELISA 宿主: 兔 Polyclonal Biotin
产品编号 ABIN7152282
发货至: 中国
  • 抗原 See all EXOSC1 抗体
    EXOSC1 (Exosome Component 1 (EXOSC1))
    抗原表位
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    AA 9-195
    适用
    • 33
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 27
    • 6
    克隆类型
    • 29
    • 4
    多克隆
    标记
    • 17
    • 5
    • 4
    • 3
    • 2
    • 2
    This EXOSC1 antibody is conjugated to Biotin
    应用范围
    • 24
    • 22
    • 5
    • 3
    • 2
    • 1
    • 1
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Exosome complex component CSL4 protein (9-195AA)
    亚型
    IgG
    Top Product
    Discover our top product EXOSC1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    EXOSC1 (Exosome Component 1 (EXOSC1))
    别名
    EXOSC1 (EXOSC1 产品)
    别名
    MGC86284 antibody, CGI-108 antibody, CSL4 antibody, Csl4p antibody, SKI4 antibody, Ski4p antibody, hCsl4p antibody, p13 antibody, 2610035C18Rik antibody, 2610104C07Rik antibody, 2610312F07Rik antibody, AI447561 antibody, exosome component 1 antibody, exosome component 1 L homeolog antibody, EXOSC1 antibody, exosc1.L antibody, exosc1 antibody, PTRG_05845 antibody, Exosc1 antibody
    背景

    Background: Non-catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.

    Aliases: 3'-5' exoribonuclease CSL4 homolog antibody, CGI 108 antibody, CGI-108 antibody, CSL4 antibody, CSL4 exosomal core protein homolog antibody, CSL4, S. cerevisiae, homolog of antibody, Csl4p antibody, EXOS1_HUMAN antibody, Exosc1 antibody, Exosomal core protein CSL4 antibody, Exosome complex component csl4 antibody, Exosome component 1 antibody, hCsl4p antibody, Homolog of yeast exosomal core protein CSL4 antibody, p13 antibody, RP11-452K12.9 antibody, SKI4 antibody, Ski4p antibody

    UniProt
    Q9Y3B2
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