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SIAH2 抗体 (AA 1-72) (Biotin)

SIAH2 适用: 人 ELISA 宿主: 兔 Polyclonal Biotin
产品编号 ABIN7151219
发货至: 中国
  • 抗原 See all SIAH2 抗体
    SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
    抗原表位
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-72
    适用
    • 36
    • 16
    • 15
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 34
    • 2
    克隆类型
    • 34
    • 2
    多克隆
    标记
    • 17
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIAH2 antibody is conjugated to Biotin
    应用范围
    • 24
    • 20
    • 20
    • 13
    • 4
    • 2
    • 2
    • 1
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human E3 ubiquitin-protein ligase SIAH2 protein (1-72AA)
    亚型
    IgG
    Top Product
    Discover our top product SIAH2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
    别名
    SIAH2 (SIAH2 产品)
    别名
    hSiah2 antibody, Xsiah-2 antibody, siah2-A antibody, xsiah2 antibody, AA415433 antibody, Sinh2 antibody, siah E3 ubiquitin protein ligase 2 antibody, siah E3 ubiquitin protein ligase 2 L homeolog antibody, seven in absentia 2 antibody, SIAH2 antibody, siah2.L antibody, Siah2 antibody
    背景

    Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA.

    Aliases: E3 ubiquitin-protein ligase Siah2 antibody, hSiah2 antibody, Seven in absentia homolog 2 antibody, Siah E3 ubiquitin protein ligase 2 antibody, Siah-2 antibody, siah2 antibody, SIAH2_HUMAN antibody, Ubiquitin Ligase Siah2 antibody

    UniProt
    O43255
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