RNF31 抗体 (AA 421-700) (Biotin)
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- 抗原 See all RNF31 抗体
- RNF31 (Ring Finger Protein 31 (RNF31))
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抗原表位
- AA 421-700
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RNF31 antibody is conjugated to Biotin
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应用范围
- ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human E3 ubiquitin-protein ligase RNF31 protein (421-700AA)
- 亚型
- IgG
- Top Product
- Discover our top product RNF31 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- RNF31 (Ring Finger Protein 31 (RNF31))
- 别名
- RNF31 (RNF31 产品)
- 别名
- RNF31 antibody, HOIP antibody, ZIBRA antibody, AL033293 antibody, BC031509 antibody, Flj10111 antibody, Paul antibody, mFLJ00217 antibody, ring finger protein 31 antibody, RNF31 antibody, rnf31 antibody, Rnf31 antibody
- 背景
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Background: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (\\\'Met-1\\\'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.
Aliases: E3 ubiquitin protein ligase RNF31 antibody, FLJ10111 antibody, FLJ23501 antibody, HOIL 1L interacting protein antibody, HOIL-1-interacting protein antibody, HOIL1L interacting protein antibody, HOIP antibody, RING finger protein 31 antibody, RNF31 antibody, RNF31_HUMAN antibody, ZIBRA antibody, Zinc in between ring finger ubiquitin associated domain antibody, Zinc in-between-RING-finger ubiquitin-associated domain protein antibody
- UniProt
- Q96EP0
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