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RNF168 抗体 (AA 194-296) (FITC)

RNF168 适用: 人 宿主: 兔 Polyclonal FITC
产品编号 ABIN7151158
发货至: 中国
  • 抗原 See all RNF168 抗体
    RNF168 (Ring Finger Protein 168 (RNF168))
    抗原表位
    • 10
    • 8
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 194-296
    适用
    • 33
    • 7
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 28
    • 4
    • 2
    克隆类型
    • 32
    • 2
    多克隆
    标记
    • 21
    • 3
    • 3
    • 3
    • 2
    • 2
    This RNF168 antibody is conjugated to FITC
    应用范围
    请咨询
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human E3 ubiquitin-protein ligase RNF168 protein (194-296AA)
    亚型
    IgG
    Top Product
    Discover our top product RNF168 Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    RNF168 (Ring Finger Protein 168 (RNF168))
    别名
    RNF168 (RNF168 产品)
    别名
    3110001H15Rik antibody, hRNF168 antibody, ring finger protein 168 antibody, ring finger protein 168, E3 ubiquitin protein ligase L homeolog antibody, Rnf168 antibody, rnf168.L antibody, RNF168 antibody
    背景

    Background: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of \'Lys-63\'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of \'Lys-63\'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate \'Lys-63\'-linked ubiquitination in vitro, possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of \'Lys-13\' and \'Lys-15\' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

    Aliases: E3 ubiquitin protein ligase RNF168 antibody, E3 ubiquitin-protein ligase RNF168 antibody, FLJ35794 antibody, FLJ39749 antibody, hRNF168 antibody, RING finger protein 168 antibody, RN168_HUMAN antibody, RNF 168 antibody, Rnf168 antibody

    UniProt
    Q8IYW5
    途径
    Production of Molecular Mediator of Immune Response
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