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RNF126 抗体 (AA 39-225) (HRP)

RNF126 适用: 人 ELISA 宿主: 兔 Polyclonal HRP
产品编号 ABIN7151137
发货至: 中国
  • 抗原 See all RNF126 抗体
    RNF126 (Ring Finger Protein 126 (RNF126))
    抗原表位
    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    AA 39-225
    适用
    • 32
    • 20
    • 4
    • 2
    • 2
    • 1
    • 1
    宿主
    • 31
    • 1
    克隆类型
    • 31
    • 1
    多克隆
    标记
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RNF126 antibody is conjugated to HRP
    应用范围
    • 23
    • 13
    • 13
    • 9
    • 3
    • 3
    • 3
    • 1
    • 1
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human E3 ubiquitin-protein ligase RNF126 protein (39-225AA)
    亚型
    IgG
    Top Product
    Discover our top product RNF126 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    RNF126 (Ring Finger Protein 126 (RNF126))
    别名
    RNF126 (RNF126 产品)
    别名
    2610010O19Rik antibody, ring finger protein 126 antibody, RNF126 antibody, Rnf126 antibody
    背景

    Background: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates \'Lys-48\'- and \'Lys-63\'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

    Aliases: E3 ubiquitin-protein ligase RNF126 antibody, FLJ20552 antibody, MGC1022 antibody, MGC14317 antibody, RING finger protein 126 antibody, RN126_HUMAN antibody, RNF 126 antibody, RNF126 antibody

    UniProt
    Q9BV68
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