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- 抗原 See all NHLRC1 抗体
- NHLRC1 (NHL Repeat Containing 1 (NHLRC1))
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抗原表位
- AA 86-395
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NHLRC1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (86-395aa)
- 亚型
- IgG
- Top Product
- Discover our top product NHLRC1 Primary Antibody
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anti-NHL Repeat Containing 1 (NHLRC1) (AA 1-280) antibody
NHLRC1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NHL Repeat Containing 1 (NHLRC1) antibodyNHLRC1 适用: 人, 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NHL Repeat Containing 1 (NHLRC1) (AA 137-246) antibodyNHLRC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G6 unconjugated
anti-NHL Repeat Containing 1 (NHLRC1) (AA 1-280) antibodyNHLRC1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-NHL Repeat Containing 1 (NHLRC1) antibodyNHLRC1 适用: 人 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:100-1:500,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- NHLRC1 (NHL Repeat Containing 1 (NHLRC1))
- 别名
- NHLRC1 (NHLRC1 产品)
- 别名
- EPM2A antibody, EPM2B antibody, MALIN antibody, bA204B7.2 antibody, AI505271 antibody, B230309E09Rik antibody, Epm2b antibody, malin-like antibody, NHL repeat containing E3 ubiquitin protein ligase 1 antibody, NHL repeat containing 1 antibody, NHLRC1 antibody, Nhlrc1 antibody
- 背景
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Background: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
Aliases: E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1), NHLRC1, EPM2B
- UniProt
- Q6VVB1
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