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- 抗原 See all PIAS1 抗体
- PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))
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抗原表位
- AA 422-651
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIAS1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human E3 SUMO-protein ligase PIAS1 protein (422-651AA)
- 亚型
- IgG
- Top Product
- Discover our top product PIAS1 Primary Antibody
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anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 636-651), (C-Term) antibody
PIAS1 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 636-651) antibodyPIAS1 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (N-Term) antibodyPIAS1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 543-651) antibodyPIAS1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4A4 unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 422-651) antibodyPIAS1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) antibodyPIAS1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (N-Term) antibodyPIAS1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 409-645) antibodyPIAS1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (C-Term) antibodyPIAS1 适用: 人, 马, Cow, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (N-Term) antibodyPIAS1 适用: 人, 小鼠, 大鼠, 马, Cow, 犬, 兔, Bat, 豚鼠, 猴, 斑马鱼, Pig, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))
- 别名
- PIAS1 (PIAS1 产品)
- 别名
- 2900068C24Rik antibody, Ddxbp1 antibody, GBP antibody, DDXBP1 antibody, GU/RH-II antibody, ZMIZ3 antibody, ddxbp1 antibody, gbp antibody, pias antibody, pias1-A antibody, xPAIS1 antibody, xPIAS1 antibody, zmiz3 antibody, protein inhibitor of activated STAT 1 antibody, protein inhibitor of activated STAT, 1 antibody, protein inhibitor of activated STAT, 1a antibody, protein inhibitor of activated STAT 1 L homeolog antibody, PIAS1 antibody, Pias1 antibody, pias1a antibody, pias1.L antibody
- 背景
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Background: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at\\\'Lys-65\\\' and \\\'Lys-160\\\') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
Aliases: AR interacting protein antibody, DDXBP1 antibody, DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1 antibody, DEAD/H box binding protein 1 antibody, DEAD/H box-binding protein 1 antibody, E3 SUMO-protein ligase PIAS1 antibody, GBP antibody, Gu binding protein antibody, Gu-binding protein antibody, GU/RH-II antibody, Pias1 antibody, PIAS1_HUMAN antibody, Protein inhibitor of activated STAT protein 1 antibody, Protein inhibitor of activated STAT, 1 antibody, RNA helicase II binding protein antibody, RNA helicase II-binding protein antibody, Zinc finger, MIZ-type containing 3 antibody, ZMIZ3 antibody
- UniProt
- O75925
- 途径
- JAK/STAT Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C
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