-
- 抗原 See all MAP2K6 抗体
- MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
-
抗原表位
- AA 1-334
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This MAP2K6 antibody is un-conjugated
-
应用范围
- ELISA, Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Dual specificity mitogen-activated protein kinase kinase 6 protein (1-334AA)
- 亚型
- IgG
- Top Product
- Discover our top product MAP2K6 Primary Antibody
-
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 46-306) antibody
MAP2K6 适用: 人 WB, ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) antibodyMAP2K6 适用: 人 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3H12C8 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 231-334) antibodyMAP2K6 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2F2 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 1-334) antibodyMAP2K6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) antibodyMAP2K6 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 3H12B9 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (pSer207) antibodyMAP2K6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (pSer189), (pSer207) antibodyMAP2K6 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 1-334) antibodyMAP2K6 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) antibodyMAP2K6 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (N-Term) antibodyMAP2K6 适用: 人, 小鼠, 大鼠, Cow, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Recommended dilution: IF:1:200-1:500,
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- 抗原
- MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
- 别名
- MAP2K6 (MAP2K6 产品)
- 别名
- MAPKK6 antibody, MEK6 antibody, MKK6 antibody, PRKMK6 antibody, SAPKK-3 antibody, SAPKK3 antibody, Mkk6 antibody, Prkmk6 antibody, MKK3 antibody, map2k3 antibody, zMKK3 antibody, map2k6 antibody, mitogen-activated protein kinase kinase 6 antibody, mitogen-activated protein kinase kinase 6 L homeolog antibody, MAP2K6 antibody, Map2k6 antibody, map2k6 antibody, map2k6.L antibody
- 背景
-
Background: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction, and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
Aliases: Dual specificity mitogen activated protein kinase kinase 6 antibody, Dual specificity mitogen-activated protein kinase kinase 6 antibody, MAP kinase kinase 6 antibody, MAP2K6 antibody, MAPK/ERK kinase 6 antibody, MAPKK 6 antibody, MAPKK6 antibody, MEK 6 antibody, MEK6 antibody, Mitogen Activated Protein Kinase Kinase 6 antibody, MKK 6 antibody, MKK6 antibody, MP2K6_HUMAN antibody, PRKMK6 antibody, protein kinase antibody, Protein kinase mitogen activated kinase 6 antibody, protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6) antibody, SAPK kinase 3 antibody, SAPKK-3 antibody, SAPKK3 antibody, SKK3 antibody, Stress-activated protein kinase kinase 3 antibody
- UniProt
- P52564
- 途径
- MAPK Pathway, TLR signaling, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades
-
You are here:
