电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

SATB1 抗体 (AA 484-763)

SATB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7150393
发货至: 中国
  • 抗原 See all SATB1 抗体
    SATB1 (SATB Homeobox 1 (SATB1))
    抗原表位
    • 16
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 484-763
    适用
    • 62
    • 47
    • 28
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    宿主
    • 54
    • 7
    • 1
    克隆类型
    • 47
    • 15
    多克隆
    标记
    • 32
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SATB1 antibody is un-conjugated
    应用范围
    • 28
    • 22
    • 14
    • 14
    • 11
    • 11
    • 11
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    交叉反应
    人, 小鼠
    纯化方法
    Antigen Affinity Purified
    免疫原
    Recombinant Human DNA-binding protein SATB1 protein (484-763AA)
    亚型
    IgG
    Top Product
    Discover our top product SATB1 Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:500-1:2000,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    SATB1 (SATB Homeobox 1 (SATB1))
    别名
    SATB1 (SATB1 产品)
    别名
    2610306G12Rik antibody, AW413156 antibody, SATB1 antibody, sb:cb955 antibody, si:ch211-195k18.2 antibody, SATB homeobox 1 antibody, special AT-rich sequence binding protein 1 antibody, SATB homeobox 1a antibody, SATB1 antibody, Satb1 antibody, satb1 antibody, satb1a antibody
    背景

    Background: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

    Aliases: DNA binding protein SATB1 antibody, DNA-binding protein SATB1 antibody, SATB homeobox 1 antibody, SATB1 antibody, SATB1_HUMAN antibody, Special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA) antibody, Special AT rich sequence binding protein 1 antibody, Special AT-rich sequence-binding protein 1 antibody

    UniProt
    Q01826
    途径
    Caspase Cascade in Apoptosis, Activated T Cell Proliferation
You are here:
客服