DMAP1 抗体 (AA 250-300)
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- 抗原 See all DMAP1 抗体
- DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))
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抗原表位
- AA 250-300
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DMAP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human DNA methyltransferase 1-associated protein 1 protein (250-300AA)
- 亚型
- IgG
- Top Product
- Discover our top product DMAP1 Primary Antibody
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))
- 别名
- DMAP1 (DMAP1 产品)
- 背景
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Background: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
Aliases: DMAP1 antibody, KIAA1425DNA methyltransferase 1-associated protein 1 antibody, DNMAP1 antibody, DNMT1-associated protein 1 antibody
- UniProt
- Q9NPF5
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