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CREB3L1 抗体 (AA 396-500) (HRP)

CREB3L1 适用: 人 ELISA 宿主: 兔 Polyclonal HRP
产品编号 ABIN7148819
发货至: 中国
  • 抗原 See all CREB3L1 抗体
    CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1))
    抗原表位
    • 7
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 396-500
    适用
    • 34
    • 13
    • 9
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    宿主
    • 31
    • 2
    • 1
    克隆类型
    • 34
    多克隆
    标记
    • 26
    • 3
    • 2
    • 1
    • 1
    • 1
    This CREB3L1 antibody is conjugated to HRP
    应用范围
    • 31
    • 15
    • 15
    • 4
    • 4
    • 4
    • 1
    • 1
    ELISA
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 1 protein (396-500AA)
    亚型
    IgG
    Top Product
    Discover our top product CREB3L1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1))
    别名
    CREB3L1 (CREB3L1 产品)
    别名
    CREB3L1 antibody, OASIS antibody, Oasis antibody, diacylglycerol kinase-like antibody, cAMP responsive element binding protein 3 like 1 antibody, cAMP responsive element binding protein 3-like 1 antibody, LOC423198 antibody, CREB3L1 antibody, Creb3l1 antibody
    背景

    Background: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813). Binds the DNA consensus sequence 5\'-GTGXGCXGC-3\' (PubMed:21767813).

    Aliases: BBF-2 homolog antibody, CAMP responsive element binding protein 3 like 1 antibody, cAMP-responsive element-binding protein 3-like protein 1 antibody, CR3L1_HUMAN antibody, Creb3l1 antibody, Cyclic AMP responsive element binding protein 3 like protein 1 antibody, OASIS antibody, Old astrocyte specifically-induced substance antibody, Processed cyclic AMP-responsive element-binding protein 3-like protein 1 antibody

    UniProt
    Q96BA8
    途径
    Thyroid Hormone Synthesis, Chromatin Binding
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