H2AFY 抗体 (AA 123-372)
-
- 抗原 See all H2AFY 抗体
- H2AFY (H2A Histone Family, Member Y (H2AFY))
-
抗原表位
- AA 123-372
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This H2AFY antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Core histone macro-H2A.1 protein (123-372AA)
- 亚型
- IgG
- Top Product
- Discover our top product H2AFY Primary Antibody
-
-
- 应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- 抗原
- H2AFY (H2A Histone Family, Member Y (H2AFY))
- 别名
- H2AFY (H2AFY 产品)
- 别名
- H2A.y antibody, H2A/y antibody, H2AF12M antibody, H2AFJ antibody, MACROH2A1.1 antibody, mH2A1 antibody, macroH2A1.2 antibody, mH2a1 antibody, macroH2A1 antibody, wu:fa93c12 antibody, zgc:136891 antibody, h2a.y antibody, h2a/y antibody, h2af12m antibody, h2afj antibody, macroh2a antibody, mh2a1 antibody, core histone macro-H2A.1 antibody, H2A histone family, member Y antibody, H2A histone family member Y antibody, H2A histone family member Y L homeolog antibody, LOC100230612 antibody, H2AFY antibody, LOC481514 antibody, H2afy antibody, h2afy antibody, h2afy.L antibody
- 背景
-
Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.
Aliases: Core histone macro h2a.1 antibody, Core histone macro-H2A.1 antibody, H2A histone family member Y antibody, H2A.y antibody, H2A/y antibody, H2AF12M antibody, H2AFJ antibody, H2afy antibody, H2AY_HUMAN antibody, Histone H2A.Y antibody, Histone macroH2A1 antibody, Histone macroH2A1.1 antibody, Histone macroH2A1.2 antibody, Macroh2a1 antibody, MACROH2A1.1 antibody, MacroH2A1.2 antibody, Medulloblastoma antigen MU MB 50.205 antibody, Medulloblastoma antigen MU-MB-50.205 antibody, mH2a antibody, mH2A1 antibody
- UniProt
- O75367
-