CHD5 抗体 (AA 1600-1699)
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- 抗原 See all CHD5 抗体
- CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
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抗原表位
- AA 1600-1699
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CHD5 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Chromodomain-helicase-DNA-binding protein 5 protein (1600-1699AA)
- 亚型
- IgG
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- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
- 别名
- CHD5 (CHD5 产品)
- 别名
- CHD-5 antibody, 4930532L22Rik antibody, AW060752 antibody, B230399N07Rik antibody, CHD5 antibody, chromodomain helicase DNA binding protein 5 antibody, potassium voltage-gated channel subfamily A regulatory beta subunit 2 antibody, CHD5 antibody, Chd5 antibody, chd5 antibody, KCNAB2 antibody
- 背景
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Background: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated \'Lys-27\' (H3K27me3) and non-methylated \'Lys-4\' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at \'Lys-27\' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
Aliases: ATP-dependent helicase CHD5 antibody, CHD 5 antibody, CHD-5 antibody, CHD5 antibody, CHD5_HUMAN antibody, Chromodomain-helicase-DNA-binding protein 5 antibody, DKFZp434N231 antibody, KIAA0444 antibody, RP1-233K16.2 antibody
- UniProt
- Q8TDI0
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