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- 抗原 See all CETN2 抗体
- CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))
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抗原表位
- AA 1-172
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CETN2 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Centrin-2 protein (1-172AA)
- 亚型
- IgG
- Top Product
- Discover our top product CETN2 Primary Antibody
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anti-Centrin, EF-Hand Protein, 2 (CETN2) (AA 1-172) antibody
CETN2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Centrin, EF-Hand Protein, 2 (CETN2) (AA 85-172) antibodyCETN2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Centrin, EF-Hand Protein, 2 (CETN2) (AA 85-172) antibodyCETN2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Centrin, EF-Hand Protein, 2 (CETN2) (AA 1-172) antibodyCETN2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Centrin, EF-Hand Protein, 2 (CETN2) (AA 1-172) antibodyCETN2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Centrin, EF-Hand Protein, 2 (CETN2) antibody (FITC)CETN2 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal FITC
anti-Centrin, EF-Hand Protein, 2 (CETN2) antibodyCETN2 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Centrin, EF-Hand Protein, 2 (CETN2) (full length) antibodyCETN2 适用: 人, 小鼠, 大鼠 WB, IF/ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))
- 别名
- CETN2 (CETN2 产品)
- 别名
- cb732 antibody, CETN2 antibody, 1110034A02Rik antibody, AI326150 antibody, Calt antibody, caltractin antibody, CALT antibody, CEN2 antibody, caltractin antibody, centrin 2 antibody, centrin 4 antibody, LOC412449 antibody, CETN2 antibody, cetn4 antibody, Cetn2 antibody
- 背景
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Background: Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5\\\'-to-3\\\' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
Aliases: 20kD calcium binding protein antibody, CALT antibody, caltractin antibody, Caltractin isoform 1 antibody, CEN2 antibody, centrin antibody, centrin, EF hand protein, 2 antibody, Centrin-2 antibody, Centrin2 antibody, CETN2 antibody, CETN2_HUMAN antibody, EF hand protein 2 antibody, EF-hand protein antibody
- UniProt
- P41208
- 途径
- DNA Damage Repair, M Phase
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