RAD9A 抗体 (AA 267-341)
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- 抗原 See all RAD9A 抗体
- RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))
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抗原表位
- AA 267-341
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RAD9A antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Cell cycle checkpoint control protein RAD9A protein (267-341AA)
- 亚型
- IgG
- Top Product
- Discover our top product RAD9A Primary Antibody
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))
- 别名
- RAD9A (RAD9A 产品)
- 别名
- RAD9 antibody, Rad9 antibody, rad9a antibody, MGC89062 antibody, XRad9 antibody, rad9 antibody, RAD9 checkpoint clamp component A antibody, RAD9 checkpoint clamp component B antibody, RAD9 checkpoint clamp component A L homeolog antibody, RAD9A antibody, Rad9a antibody, rad9a antibody, rad9b antibody, rad9a.L antibody
- 背景
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Background: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3\'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3\'->5\' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
Aliases: Cell cycle checkpoint control protein antibody, Cell cycle checkpoint control protein RAD9A antibody, DNA repair exonuclease rad9 homolog A antibody, hRAD 9 antibody, hRAD9 antibody, Rad 9 antibody, RAD 9A antibody, RAD9 (S pombe) homolog antibody, RAD9 homolog A antibody, RAD9 homolog antibody, Rad9a antibody, RAD9A_HUMAN antibody
- UniProt
- Q99638
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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