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CSNK2A1/CK II alpha 抗体 (AA 1-391)

CSNK2A1 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7146885
发货至: 中国
  • 抗原 See all CSNK2A1/CK II alpha (CSNK2A1) 抗体
    CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))
    抗原表位
    • 11
    • 11
    • 7
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    AA 1-391
    适用
    • 85
    • 59
    • 55
    • 7
    • 6
    • 6
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    • 4
    • 4
    • 4
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    • 1
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    宿主
    • 79
    • 6
    克隆类型
    • 78
    • 7
    多克隆
    标记
    • 52
    • 5
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    • 1
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    This CSNK2A1/CK II alpha antibody is un-conjugated
    应用范围
    • 72
    • 36
    • 25
    • 8
    • 8
    • 8
    • 4
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Casein kinase II subunit alpha protein (1-391AA)
    亚型
    IgG
    Top Product
    Discover our top product CSNK2A1 Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200, IP:1:200-1:2000,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))
    别名
    CSNK2A1 (CSNK2A1 产品)
    别名
    CK2A2 antibody, CSNK2A1 antibody, CK2A1 antibody, CKII antibody, CSNK2A3 antibody, CK2A antibody, Ck2a antibody, BmCK2a antibody, wu:fi38e04 antibody, wu:fi38h03 antibody, csnk2a1 antibody, CK-II antibody, CK2 antibody, Ckiialpha antibody, Csnk2a1-rs4 antibody, ck2a1 antibody, casein kinase 2 alpha 2 antibody, casein kinase 2 alpha 1 antibody, casein kinase 2 alpha subunit antibody, casein kinase 2, alpha 1 polypeptide antibody, CK2 protein kinase alpha 2 antibody, casein kinase II alpha subunit antibody, Casein kinase II alpha subunit antibody, casein kinase 2, alpha 1 polypeptide S homeolog antibody, CSNK2A2 antibody, CSNK2A1 antibody, ck2a antibody, Ck2a antibody, csnk2a1 antibody, cka2 antibody, Ckiialpha antibody, CK2A1 antibody, Csnk2a1 antibody, csnk2a1.S antibody
    背景

    Background: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating \\\'Ser-392\\\' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at \\\'Ser-565\\\' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at \\\'Ser-90\\\' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.

    Aliases: Casein kinase 2 alpha 1 polypeptide antibody, Casein kinase II alpha 1 antibody, Casein kinase II alpha 1 subunit antibody, Casein kinase II alpha subunit antibody, Casein kinase II subunit alpha antibody, CK II alpha antibody, CK II antibody, CK2 alpha antibody, CK2 catalytic subunit alpha antibody, CK2A1 antibody, CKII antibody, CKIIalpha antibody, CSK21_HUMAN antibody, CSNK2A1 antibody

    UniProt
    P68400
    途径
    SARS-CoV-2 Protein Interactome
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