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MICU1 抗体 (AA 55-191)

MICU1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7146322
发货至: 中国
  • 抗原 See all MICU1 抗体
    MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))
    抗原表位
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 55-191
    适用
    • 31
    • 9
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 24
    • 7
    • 1
    克隆类型
    • 26
    • 6
    多克隆
    标记
    • 15
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MICU1 antibody is un-conjugated
    应用范围
    • 21
    • 13
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Calcium uptake protein 1, mitochondrial protein (55-191AA)
    亚型
    IgG
    Top Product
    Discover our top product MICU1 Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))
    别名
    MICU1 (MICU1 产品)
    别名
    CALC antibody, CBARA1 antibody, EFHA3 antibody, C730016L05Rik antibody, Calc antibody, Cbara1 antibody, mitochondrial calcium uptake 1 antibody, MICU1 antibody, Micu1 antibody
    背景

    Background: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

    Aliases: Allergen Hom s 4 antibody, ara CALC antibody, atopy related autoantigen antibody, atopy related autoantigen CALC antibody, Atopy-related autoantigen CALC antibody, CALC antibody, calcium binding atopy related autoantigen 1 antibody, Calcium uptake protein 1 antibody, calcium uptake protein 1, mitochondrial antibody, Calcium-binding atopy-related autoantigen 1 antibody, CBARA1 antibody, EFHA3 antibody, FLJ12684 antibody, MICU1 antibody, MICU1_HUMAN antibody, mitochondrial antibody, mitochondrial calcium uptake 1 antibody, MPXPS antibody

    UniProt
    Q9BPX6
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