ZNF224 抗体 (AA 206-463) (FITC)
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- 抗原 See all ZNF224 抗体
- ZNF224 (Zinc Finger Protein 224 (ZNF224))
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抗原表位
- AA 206-463
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ZNF224 antibody is conjugated to FITC
- 应用范围
- 请咨询
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human BUB3-interacting and GLEBS motif-containing protein ZNF207 protein (206-463AA)
- 亚型
- IgG
- Top Product
- Discover our top product ZNF224 Primary Antibody
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- ZNF224 (Zinc Finger Protein 224 (ZNF224))
- 别名
- ZNF27 (ZNF224 产品)
- 别名
- BMZF-2 antibody, BMZF2 antibody, KOX22 antibody, ZNF255 antibody, ZNF27 antibody, zinc finger protein 224 antibody, ZNF224 antibody
- 背景
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Background: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
Aliases: Zinc finger protein 207 antibody, ZN207_HUMAN antibody, ZNF 207 antibody, ZNF207 antibody
- UniProt
- O43670
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