KCTD6 抗体 (AA 1-237) (Biotin)
-
- 抗原 See all KCTD6 抗体
- KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))
-
抗原表位
- AA 1-237
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This KCTD6 antibody is conjugated to Biotin
-
应用范围
- ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)
- 亚型
- IgG
- Top Product
- Discover our top product KCTD6 Primary Antibody
-
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- 抗原
- KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))
- 别名
- KCTD6 (KCTD6 产品)
- 别名
- KCTD6 antibody, 5430433B02Rik antibody, AU044285 antibody, kctd6 antibody, zgc:91884 antibody, KCASH3 antibody, potassium channel tetramerization domain containing 6 antibody, potassium channel tetramerisation domain containing 6 antibody, potassium channel tetramerization domain containing 6b antibody, KCTD6 antibody, kctd6 antibody, Kctd6 antibody, kctd6b antibody
- 背景
-
Background: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1, the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1, the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).
Aliases: BTB/POZ domain-containing protein KCTD6 antibody, KCASH3 antibody, kctd6 antibody, KCTD6_HUMAN antibody, MGC27385 antibody, potassium channel tetramerization domain containing 6 antibody
- UniProt
- Q8NC69
-