BRD7 抗体 (AA 601-651)
-
- 抗原 See all BRD7 抗体
- BRD7 (Bromodomain Containing 7 (BRD7))
-
抗原表位
- AA 601-651
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This BRD7 antibody is un-conjugated
-
应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Bromodomain-containing protein 7 protein (601-651AA)
- 亚型
- IgG
- Top Product
- Discover our top product BRD7 Primary Antibody
-
-
- 应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- 抗原
- BRD7 (Bromodomain Containing 7 (BRD7))
- 别名
- BRD7 (BRD7 产品)
- 别名
- zgc:66347 antibody, wu:fc95f02 antibody, MGC79478 antibody, BRD7 antibody, BP75 antibody, CELTIX1 antibody, NAG4 antibody, Ptpn13ip antibody, bromodomain containing 7 L homeolog antibody, bromodomain containing 7 antibody, brd7.L antibody, brd7 antibody, BRD7 antibody, Brd7 antibody
- 背景
-
Background: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at \\\'Tyr-216\\\'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at \\\'Lys-9\\\' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at \\\'Lys-382\\\', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
Aliases: 75 kDa bromodomain protein antibody, BP75 antibody, BRD 7 antibody, BRD7 antibody, BRD7_HUMAN antibody, Bromodomain containing 7 antibody, bromodomain containing protein 7 antibody, Bromodomain-containing protein 7 antibody, CELTIX 1 antibody, CELTIX1 antibody, NAG4 antibody, Protein CELTIX-1 antibody
- UniProt
- Q9NPI1
-