Survivin 抗体 (AA 1-130)
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- 抗原 See all Survivin (BIRC5) 抗体
- Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))
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抗原表位
- AA 1-130
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Survivin antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Baculoviral IAP repeat-containing protein 5 protein (1-130AA)
- 亚型
- IgG
- Top Product
- Discover our top product BIRC5 Primary Antibody
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- 应用备注
- Recommended dilution: IF:1:50-1:500,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))
- 别名
- BIRC5 (BIRC5 产品)
- 别名
- AP14 antibody, API4 antibody, EPR-1 antibody, AAC-11 antibody, Api4 antibody, TIAP antibody, survivin40 antibody, bir5a antibody, survivin antibody, BIR1 antibody, Su2 antibody, XBIR1 antibody, XSurvivin1 antibody, Xsvv1 antibody, api4 antibody, bir1-A antibody, epr-1 antibody, svv1 antibody, xSurvivin antibody, xsurv antibody, Su1 antibody, birc5.2 antibody, svv2 antibody, xSurvivin2 antibody, bir5b antibody, SIX antibody, birc5.2-a antibody, birc5.2-b antibody, baculoviral IAP repeat containing 5 antibody, baculoviral IAP repeat-containing 5 antibody, baculoviral IAP repeat containing 5a antibody, baculoviral IAP repeat-containing 5, gene 1 L homeolog antibody, baculoviral IAP repeat containing 5 L homeolog antibody, baculoviral IAP repeat containing 5b antibody, baculoviral IAP repeat containing 5 S homeolog antibody, BIRC5 antibody, Birc5 antibody, birc5a antibody, birc5.1.L antibody, birc5.2.L antibody, birc5b antibody, birc5.2.S antibody
- 背景
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Background: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex, directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at \'Thr-3\' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
Aliases: API4 antibody, Apoptosis inhibitor 4 antibody, Apoptosis inhibitor survivin antibody, Apoptosis inhibitor4 antibody, Baculoviral IAP repeat containing 5 antibody, Baculoviral IAP repeat containing protein 5 antibody, Baculoviral IAP repeat-containing protein 5 antibody, BIRC 5 antibody, BIRC5 antibody, BIRC5_HUMAN antibody, EPR 1 antibody, IAP4 antibody, Survivin variant 3 alpha antibody, SVV antibody, TIAP antibody
- UniProt
- O15392
- 途径
- Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding
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