Angiopoietin 1 抗体 (AA 16-498)
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- 抗原 See all Angiopoietin 1 (ANGPT1) 抗体
- Angiopoietin 1 (ANGPT1)
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抗原表位
- AA 16-498
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Angiopoietin 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Angiopoietin-1 protein (16-498AA)
- 亚型
- IgG
- Top Product
- Discover our top product ANGPT1 Primary Antibody
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anti-Angiopoietin 1 (ANGPT1) (AA 304-450) antibody
ANGPT1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 260-400) antibodyANGPT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (Internal Region) antibodyVerified ANGPT1 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 276-375) antibodyANGPT1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 21-228) antibodyANGPT1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 284-452) antibodyANGPT1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 253-429) antibodyANGPT1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (N-Term) antibodyANGPT1 适用: 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) antibodyANGPT1 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 284-452) antibodyANGPT1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
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- 应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- Angiopoietin 1 (ANGPT1)
- 别名
- ANGPT1 (ANGPT1 产品)
- 别名
- AGP1 antibody, AGPT antibody, ANG1 antibody, 1110046O21Rik antibody, Ang-1 antibody, Ang1 antibody, Agpt antibody, Agpt1 antibody, ang1 antibody, wu:fc76g06 antibody, ANG-1 antibody, angpt1 antibody, MGC80788 antibody, angiopoietin 1 antibody, angiopoietin 1 S homeolog antibody, ANGPT1 antibody, Angpt1 antibody, angpt1 antibody, angpt1.S antibody
- 背景
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Background: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
Aliases: AGP 1 antibody, AGP1 antibody, AGPT antibody, ANG 1 antibody, ANG antibody, ANG-1 antibody, ANG1 antibody, Angiopoietin-1 antibody, Angiopoietin1 antibody, ANGP1_HUMAN antibody, ANGPT 1 antibody, Angpt1 antibody, KIAA0003 antibody, OTTHUMP00000227592 antibody, OTTHUMP00000227599 antibody, OTTHUMP00000227600 antibody
- UniProt
- Q15389
- 途径
- RTK signaling, Glycosaminoglycan Metabolic Process
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