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- 抗原 See all STK4 抗体
- STK4 (serine/threonine Kinase 4 (STK4))
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抗原表位
- AA 6-24
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This STK4 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Peptide sequence from Human Serine/threonine-protein kinase 4 protein (6-24AA)
- 亚型
- IgG
- Top Product
- Discover our top product STK4 Primary Antibody
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anti-serine/threonine Kinase 4 (STK4) (AA 391-485) antibody
STK4 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4F4 unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 1-39) antibodySTK4 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D7-8A10 unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 303-487) antibodySTK4 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (C-Term) antibodyKO Validated STK4 适用: 人 WB, IP, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 391-485) antibodySTK4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) antibodySTK4 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 385-415) antibodySTK4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (pThr183) antibodySTK4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 320-420) antibody (HRP)STK4 适用: 人 WB, IHC 宿主: 兔 Polyclonal HRP
anti-serine/threonine Kinase 4 (STK4) (AA 320-420) antibody (FITC)STK4 适用: 人 WB, IHC 宿主: 兔 Polyclonal FITC
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- 应用备注
- Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- STK4 (serine/threonine Kinase 4 (STK4))
- 别名
- STK4 (STK4 产品)
- 别名
- KRS2 antibody, MST1 antibody, TIIAC antibody, YSK3 antibody, AI447339 antibody, AU020804 antibody, Kas-2 antibody, Mst1 antibody, Ysk3 antibody, krs2 antibody, mst1 antibody, ysk3 antibody, serine/threonine kinase 4 antibody, serine/threonine kinase 4 S homeolog antibody, STK4 antibody, Stk4 antibody, stk4.S antibody
- 背景
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Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates \'Ser-14\' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on \'Ser-212\' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on \'Ser-650\' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
Aliases: Kinase responsive to stress antibody, Krs2 antibody, Mammalian STE20 like protein kinase 1 antibody, Mammalian STE20-like protein kinase 1 antibody, Mammalian sterile 20 like 1 antibody, MST-1 antibody, MST1 antibody, Serine/threonine kinase 4 antibody, Serine/threonine protein kinase Krs 2 antibody, Serine/threonine-protein kinase 4 antibody, Serine/threonine-protein kinase Krs-2 antibody, STE20 like kinase MST1 antibody, STE20-like kinase MST1 antibody, STK4 antibody, STK4_HUMAN antibody, TIIAC antibody, YSK3 antibody
- UniProt
- Q13043
- 途径
- Tube Formation
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