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UBC 抗体 (AA 19-36) (FITC)

UBC 适用: 人 宿主: 兔 Polyclonal FITC
产品编号 ABIN7140062
发货至: 中国
  • 抗原 See all UBC 抗体
    UBC (Ubiquitin C (UBC))
    抗原表位
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 19-36
    适用
    • 15
    • 2
    • 2
    宿主
    • 15
    克隆类型
    • 15
    多克隆
    标记
    • 13
    • 1
    • 1
    This UBC antibody is conjugated to FITC
    应用范围
    请咨询
    交叉反应
    纯化方法
    Antigen Affinity Purified
    免疫原
    Peptide sequence from Human Polyubiquitin-C protein (19-36AA)
    亚型
    IgG
    Top Product
    Discover our top product UBC Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    UBC (Ubiquitin C (UBC))
    别名
    UBC (UBC 产品)
    别名
    HMG20 antibody, 2700054O04Rik antibody, AI194771 antibody, Rps27a antibody, TI-225 antibody, Uba52 antibody, Ubb antibody, ubiquitin C antibody, UBC antibody, Ubc antibody
    背景

    Background: Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair, Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation, Lys-29-linked is involved in lysosomal degradation, Lys-33-linked is involved in kinase modification, Lys-48-linked is involved in protein degradation via the proteasome, Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

    Aliases: UBC antibody, Polyubiquitin-C [Cleaved into: Ubiquitin] antibody

    UniProt
    P0CG48
    途径
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, EGFR Downregulation, Ubiquitin Proteasome Pathway
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