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- 抗原 See all Mu Opioid Receptor 1 (OPRM1) 抗体
- Mu Opioid Receptor 1 (OPRM1) (Opioid Receptor, mu 1 (OPRM1))
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抗原表位
- pSer375
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Mu Opioid Receptor 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- 免疫原
- Peptide sequence around phosphorylation site of serine 375(H-P-S(p)-T-A) derived from Human Opioid Receptor.
- 亚型
- IgG
- Top Product
- Discover our top product OPRM1 Primary Antibody
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anti-Opioid Receptor, mu 1 (OPRM1) (C-Term) antibody
OPRM1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, mu 1 (OPRM1) (pSer375) antibodyOPRM1 适用: 小鼠 WB, IHC (p), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, mu 1 (OPRM1) (AA 165-270) antibodyOPRM1 适用: 小鼠, 大鼠 WB, IHC (p), IF (p), ICC, IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, mu 1 (OPRM1) (AA 1-68) antibodyOPRM1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, mu 1 (OPRM1) (C-Term) antibodyOPRM1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, mu 1 (OPRM1) (AA 161-187) antibodyOPRM1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22405 unconjugated
anti-Opioid Receptor, mu 1 (OPRM1) (AA 22-38), (Extracellular), (N-Term) antibodyOPRM1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, mu 1 (OPRM1) (pSer375) antibodyOPRM1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Opioid Receptor, mu 1 (OPRM1) (AA 1-110) antibodyOPRM1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Opioid Receptor, mu 1 (OPRM1) (C-Term) antibodyOPRM1 适用: 人, 猴, Cow, Pig, 犬, Hamster, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB:1:500-1:1000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- Mu Opioid Receptor 1 (OPRM1) (Opioid Receptor, mu 1 (OPRM1))
- 别名
- OPRM1 (OPRM1 产品)
- 别名
- LMOR antibody, M-OR-1 antibody, MOP antibody, MOR antibody, MOR1 antibody, OPRM antibody, MOP-R antibody, MOR-1 antibody, MOR-1O antibody, Oprm antibody, mor antibody, muOR antibody, MORA antibody, Oprrm1 antibody, or2 antibody, ZFOR2 antibody, OPRM1 antibody, opioid receptor mu 1 antibody, opioid receptor, mu 1 antibody, outer membrane protein OprM antibody, OPRM1 antibody, Oprm1 antibody, oprm1 antibody, oprM1 antibody
- 背景
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Background:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity.
Aliases: hMOP antibody; LMOR antibody; M-OR-1 antibody; MOP antibody; MOR antibody; MOR-1 antibody; MOR1 antibody; Mu opiate receptor antibody; Mu opioid receptor antibody; Mu-type opioid receptor antibody; Opioid receptor mu 1 antibody; OPRM antibody; OPRM_HUMAN antibody; OPRM1 antibody
- UniProt
- P35372
- 途径
- cAMP Metabolic Process, Synaptic Membrane
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