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Progesterone Receptor 抗体 (pSer190)

Name: Progesterone Receptor 抗体 (pSer190)
Brand: antibodies-online
SKU: ABIN7138462
Availability: OutOfStock

PGR 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts from SKOV3 cells untreated(lane 1) or treated with EGF(lane 2) using Progesterone Receptor(Phospho-Ser190) Antibody. (Progesterone Receptor 抗体 (pSer190))

Immunofluorescence staining of methanol-fixed MCF cells using Progesterone Receptor(Phospho-Ser190) Antibody. (Progesterone Receptor 抗体 (pSer190))

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Progesterone Receptor(Phospho-Ser190) Antibody. (Progesterone Receptor 抗体 (pSer190))

IHC

3 images

产品编号 ABIN7138462

发货至: 中国

Datasheet as PDF

抗原 See all Progesterone Receptor (PGR) 抗体

Progesterone Receptor (PGR)
抗原表位
16

15

15

14

13

12

11

10

10

8

8

8

7

7

7

7

6

6

5

5

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer190
适用
246

47

43

16

15

8

6

6

5

3

3

2

1

1

1

1

1
人
宿主
187

62

1

1
兔
Compatible Secondaries
克隆类型
184

67
多克隆
标记
122

21

11

11

8

7

6

6

6

6

6

6

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1
This Progesterone Receptor antibody is un-conjugated
应用范围
178

89

59

32

28

26

26

22

18

18

17

10

6

3

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

交叉反应

人

纯化方法

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

免疫原

Peptide sequence around phosphorylation site of serine 190 (G-L-S(p)-P-A) derived from Human Progesterone Receptor.

亚型

IgG

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anti-Progesterone Receptor (PGR) (pSer400) antibody
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anti-Progesterone Receptor (PGR) (pSer294) antibody
PGR 适用: 人, 大鼠, 小鼠, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

限制

仅限研究用
状态

Liquid

缓冲液

Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

Progesterone Receptor (PGR)

别名

PGR (PGR 产品)

别名

NR3C3 antibody, PR antibody, 9930019P03Rik antibody, BB114106 antibody, ENSMUSG00000074510 antibody, PR-A antibody, PR-B antibody, XPR-1 antibody, pgr antibody, xpr-2 antibody, LOC443444 antibody, PGR antibody, pg antibody, pr antibody, gb:dq017620 antibody, progesterone receptor antibody, progesterone receptor L homeolog antibody, PGR antibody, Pgr antibody, pgr.L antibody, pgr antibody

背景

Background: Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

Narayanan R, et al. (2005) Mol Cell Biol, 25(8): 2885-98.
Knotts TA, et al. (2001) J Biol Chem, 276(11): 8475-83.
Clemm DL, et al. (2000) Mol Endocrinol, 14(1): 52-65.
Zhang Y, et al. (1997) Mol Endocrinol, 11(6): 823-32
Aliases: NR3C3 antibody, Nuclear receptor subfamily 3 group C member 3 antibody, PGR antibody, PR antibody, PRA antibody, PRB antibody, PRGR_HUMAN antibody, Progesterone receptor antibody, Progestin receptor form A antibody, Progestin receptor form B antibody

UniProt

P06401

途径

Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration