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- 抗原 See all SPATA13 抗体
- SPATA13 (Spermatogenesis Associated 13 (SPATA13))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SPATA13 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人, 小鼠
- 纯化方法
- Antigen affinity purification
- 免疫原
- Fusion protein of Human SPATA13
- 亚型
- IgG
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anti-Spermatogenesis Associated 13 (SPATA13) (AA 204-232) antibody
SPATA13 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB27015 unconjugated
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- 应用备注
- ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- SPATA13 (Spermatogenesis Associated 13 (SPATA13))
- 别名
- SPATA13 (SPATA13 产品)
- 背景
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Background: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.
Aliases: APC-stimulated guanine nucleotide exchange factor 2 antibody, ARHGEF29 antibody, Asef2 antibody, FLJ31208 antibody, RP11-307N16.3 antibody, Spata13 antibody, Spermatogenesis-associated protein 13 antibody, SPT13_HUMAN antibody
- UniProt
- Q96N96
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