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ADD2 抗体

ADD2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7128257
发货至: 中国
  • 抗原 See all ADD2 抗体
    ADD2 (Adducin 2 (Beta) (ADD2))
    适用
    • 28
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    • 9
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    • 2
    • 2
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    宿主
    • 41
    • 2
    克隆类型
    • 43
    多克隆
    标记
    • 22
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    This ADD2 antibody is un-conjugated
    应用范围
    • 36
    • 13
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    • 5
    • 3
    • 3
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    ELISA, Immunohistochemistry (IHC)
    交叉反应
    纯化方法
    Antigen affinity purification
    免疫原
    Fusion protein of Human ADD2
    亚型
    IgG
    Top Product
    Discover our top product ADD2 Primary Antibody
  • 应用备注
    ELISA:1:1000-1:2000, IHC:1:15-1:50,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    ADD2 (Adducin 2 (Beta) (ADD2))
    别名
    ADD2 (ADD2 产品)
    别名
    si:dkey-202n14.5 antibody, ADDB antibody, 2900072M03Rik antibody, add97 antibody, beta-ADD antibody, adducin 2 antibody, adducin 2 (beta) antibody, ADD2 antibody, add2 antibody, Add2 antibody
    背景

    Background: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

    Aliases: ADD 2 antibody, ADD2 antibody, ADDB antibody, ADDB_HUMAN antibody, Adducin 2 (beta) antibody, Adducin2 antibody, Beta adducin antibody, Beta-adducin antibody, Erythrocyte adducin subunit beta antibody, OTTHUMP00000203378 antibody, OTTHUMP00000203908 antibody

    UniProt
    P35612
    途径
    Regulation of Actin Filament Polymerization
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