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Recombinant RHOA 抗体

RHOA 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 1C11 unconjugated Recombinant Antibody
产品编号 ABIN7127793
发货至: 中国
  • 抗原 See all RHOA 抗体
    RHOA (Ras Homolog Gene Family, Member A (RHOA))
    抗体类型
    Recombinant Antibody
    适用
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    宿主
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    克隆类型
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    单克隆
    标记
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    This RHOA antibody is un-conjugated
    应用范围
    • 48
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    Western Blotting (WB), ELISA
    交叉反应
    纯化方法
    Affinity-chromatography
    免疫原
    A synthesized peptide derived from human Rho
    克隆位点
    1C11
    亚型
    IgG
    Top Product
    Discover our top product RHOA Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:500-1:5000,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    RHOA (Ras Homolog Gene Family, Member A (RHOA))
    别名
    RHOA (RHOA 产品)
    别名
    ARH12 antibody, ARHA antibody, RHO12 antibody, RHOH12 antibody, Arha antibody, Arha1 antibody, Arha2 antibody, arha antibody, arha2 antibody, xrhoa antibody, arh12 antibody, rho12 antibody, rhoh12 antibody, rhoa antibody, RHO1 antibody, Rhoa antibody, wu:fa66g04 antibody, wu:fb26g07 antibody, zgc:66058 antibody, zgc:85805 antibody, ARHC antibody, rhoae antibody, zgc:64015 antibody, ras homolog family member A antibody, ras homolog family member A S homeolog antibody, ras homolog family member A L homeolog antibody, ras homolog gene family, member Aa antibody, ras homolog family member Ca antibody, RHOA antibody, Rhoa antibody, rhoa.S antibody, rhoa antibody, rhoa.L antibody, rhoaa antibody, rhoca antibody
    背景

    Background: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation, promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695).

    Aliases: Transforming protein RhoA (Rho cDNA clone 12) (h12), RHOA, ARH12 ARHA RHO12

    UniProt
    P61586
    途径
    Microtubule Dynamics, WNT signaling, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, SARS-CoV-2 Protein Interactome
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