Recombinant PAK2 抗体
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- 抗原 See all PAK2 抗体
- PAK2 (P21-Activated Kinase 2 (PAK2))
- 抗体类型
- Recombinant Antibody
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This PAK2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Affinity-chromatography
- 免疫原
- A synthesized peptide derived from human PAK2
- 克隆位点
- 6D12
- 亚型
- IgG
- Top Product
- Discover our top product PAK2 Primary Antibody
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anti-P21-Activated Kinase 2 (PAK2) (AA 131-230) antibody
PAK2 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1E1 unconjugated
anti-P21-Activated Kinase 2 (PAK2) antibodyPAK2 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3B5 unconjugated
anti-P21-Activated Kinase 2 (PAK2) (AA 1-212) antibodyPAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (AA 177-419) antibodyPAK2 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (AA 192-222) antibodyPAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibodyPAK2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (pSer20) antibodyPAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (Ser62) antibodyPAK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (Ser192) antibodyPAK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (pSer197) antibodyPAK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, FC:1:20-1:200, IP:1:200-1:1000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PAK2 (P21-Activated Kinase 2 (PAK2))
- 别名
- PAK2 (PAK2 产品)
- 别名
- PAK65 antibody, PAKgamma antibody, gamma-PAK antibody, 5330420P17Rik antibody, A130002K10Rik antibody, AI836325 antibody, D16Ertd269e antibody, PAK-2 antibody, mKIAA4182 antibody, pak2 antibody, cb422 antibody, kinase antibody, zgc:91798 antibody, wu:fb71h01 antibody, si:dz198m22.1 antibody, pak65 antibody, pakgamma antibody, PAKI antibody, Pak3 antibody, CH73-159L23.1 antibody, wu:fc52b03 antibody, zgc:113857 antibody, p21 (RAC1) activated kinase 2 antibody, p21 protein (Cdc42/Rac)-activated kinase 2 antibody, p21 protein (Cdc42/Rac)-activated kinase 2a antibody, p21 protein (Cdc42/Rac)-activated kinase 2 S homeolog antibody, p21 protein (Cdc42/Rac)-activated kinase 2b antibody, PAK2 antibody, Pak2 antibody, pak2a antibody, pak2.S antibody, pak2b antibody
- 背景
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Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.
Aliases: Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27), PAK-2p34 (p34) (C-t-PAK2)], PAK2
- UniProt
- Q13177
- 途径
- MAPK Pathway, RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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