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Recombinant AIF 抗体

AIFM1 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 4B2 unconjugated Recombinant Antibody
产品编号 ABIN7127329
发货至: 中国
  • 抗原 See all AIF (AIFM1) 抗体
    AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))
    抗体类型
    Recombinant Antibody
    适用
    • 104
    • 58
    • 55
    • 22
    • 11
    • 11
    • 7
    • 7
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    • 5
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    • 1
    • 1
    宿主
    • 92
    • 9
    • 2
    • 2
    克隆类型
    • 90
    • 14
    单克隆
    标记
    • 63
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
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    • 1
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    This AIF antibody is un-conjugated
    应用范围
    • 80
    • 34
    • 30
    • 28
    • 22
    • 14
    • 13
    • 13
    • 12
    • 7
    • 5
    • 4
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    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    交叉反应
    人, 大鼠
    纯化方法
    Affinity-chromatography
    免疫原
    A synthesized peptide derived from human AIF
    克隆位点
    4B2
    亚型
    IgG
    Top Product
    Discover our top product AIFM1 Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))
    别名
    AIFM1 (AIFM1 产品)
    背景

    Background: Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

    Aliases: Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8), AIFM1, AIF PDCD8

    UniProt
    O95831
    途径
    Apoptosis, Positive Regulation of Endopeptidase Activity, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Warburg Effect
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