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Recombinant Prostate Specific Antigen 抗体 (AA 150-250)

PSA 适用: 人 IHC (f) 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
产品编号 ABIN7126557
发货至: 中国
  • 抗原 See all Prostate Specific Antigen (PSA) 抗体
    Prostate Specific Antigen (PSA)
    抗体类型
    Recombinant Antibody
    抗原表位
    • 16
    • 7
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    AA 150-250
    适用
    • 166
    • 10
    • 5
    • 4
    • 1
    • 1
    宿主
    • 93
    • 66
    • 4
    • 3
    • 2
    克隆类型
    • 105
    • 64
    单克隆
    标记
    • 106
    • 13
    • 11
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
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    This Prostate Specific Antigen antibody is un-conjugated
    应用范围
    • 76
    • 65
    • 39
    • 31
    • 25
    • 24
    • 12
    • 12
    • 11
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    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    特异性
    Prostate-specific antigen (PSA) is a single-chain glycoprotein of 237 amino acids containing approximately 8 % carbohydrate. It is a serine protease produced almost exclusively by prostatic epithelial cells. Immunohistochemically PSA is expressed in the highly specialized apically-superficial layer of female and male secretory cells of the prostate gland, and is readily demonstrated in adenocarcinomas of the prostate in about 99 % of the cases. There is a correlation between malignancy grade and intensity of staining, high grade carcinomas displaying weaker expression. About 1 % of poorly differentiated carcinomas have been negative for PSA. Due to the high specificity of PSA for prostatic glandular epithelium, it is very useful in identifying prostatic carcinoma in the prostate and in the adjacent organs often affected by epithelial malignancies, i.e. rectum and urinary bladder. PSA may be used in a panel together with NKX3.1 and Prostein, which are at least as sensitive and slightly more specific than PSA.
    交叉反应 (详细)
    Human.
    纯化方法
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    免疫原
    Synthetic peptide corresponding to PSA residues within aa150-250 of PSA was used as an immunogen.
    亚型
    IgG
    Top Product
    Discover our top product PSA Primary Antibody
  • 应用备注

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Positive_Control: PC12 cells. Normal prostate or prostate carcinoma tissues.

    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    储存液
    Azide free
    储存条件
    -20 °C,-80 °C
    储存方法
    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    有效期
    24 months
  • 抗原
    Prostate Specific Antigen (PSA)
    别名
    KLK3 (PSA 产品)
    别名
    APS antibody, KLK2A1 antibody, PSA antibody, hK3 antibody, KLK3 antibody, Klk1c10l2 antibody, RSGK-50 antibody, RSKG-50 antibody, rGK-3 antibody, Kal-3 antibody, Kal3 antibody, Klk3 antibody, AAP-S antibody, MP100 antibody, Psa antibody, R74825 antibody, goku antibody, kallikrein related peptidase 3 antibody, kallikrein 3 antibody, kallikrein 1-related peptidase C3 antibody, kallikrein B, plasma 1 antibody, aminopeptidase puromycin sensitive antibody, KLK3 antibody, Klk1c3 antibody, Klkb1 antibody, Npepps antibody
    背景
    Antigen, prostate-specific (APS), Gamma-seminoprotein, hK3, Kallikrein related peptidase 3, Kallikrein-3 (KLK3), KLK2A1, P-30 antigen, Semenogelase, Seminin,Prostate Specific Antigen (PSA)
    Cellular localisation: Secreted
    分子量
    29kDa
    基因ID
    354, 171995
    UniProt
    P07288
    途径
    Complement System
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