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- 抗原 See all SMNDC1 抗体
- SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SMNDC1 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF)
- 特异性
- SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.
- 交叉反应 （详细）
- Human.
- 纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
- 免疫原
- Recombinant full-length human SMNDC1 protein
- 亚型
- IgG2b
- Top Product
- Discover our top product SMNDC1 Primary Antibody
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anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) antibody
SMNDC1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (AA 1-238) antibodySMNDC1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (AA 1-238) antibodySMNDC1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2B9 unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (AA 1-238) antibodySMNDC1 适用: 人 ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (AA 1-238) antibodySMNDC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) antibodySMNDC1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (C-Term) antibodySMNDC1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 山羊, 马, 小鸡, Pig, 非洲爪蟾, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (C-Term) antibodySMNDC1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (AA 11-41), (N-Term) antibodySMNDC1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB17335 unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (Middle Region) antibodySMNDC1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 山羊, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Positive Control: HeLa or HepG2 cells.
Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
- 有效期
- 24 months
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- 抗原
- SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))
- 别名
- SMNDC1 (SMNDC1 产品)
- 别名
- smnr antibody, spf30 antibody, SMNDC1 antibody, SMNR antibody, SPF30 antibody, TDRD16C antibody, wu:fb37h07 antibody, wu:fc23a07 antibody, 2410004J23Rik antibody, 4933440I19Rik antibody, survival motor neuron domain containing 1 antibody, smndc1 antibody, SMNDC1 antibody, Bm1_41545 antibody, Smndc1 antibody
- 背景
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30 kDa splicing factor SMNrp, MGC106917, MGC112663, SMN related protein, SMNR, SPF30, Splicing factor 30, survival of motor neuron-related, Survival motor neuron domain containing protein 1, Survival of motor neuron related splicing factor 30,SMNDC1
Cellular localisation: Nucleus. Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies. - 分子量
- 30kDa
- 基因ID
- 10285, 632093
- UniProt
- O75940
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