Cadherin-16 抗体 (AA 371-507) (Biotin)
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- 抗原 See all Cadherin-16 (CDH16) 抗体
- Cadherin-16 (CDH16)
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抗原表位
- AA 371-507
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Cadherin-16 antibody is conjugated to Biotin
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Coating (Coat)
- 特异性
- This MAb recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport.It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells.Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
- 交叉反应 (详细)
- Human.
- 纯化方法
- Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin.
- 免疫原
- Recombinant fragment (around aa 371-507) of human CDH16 protein (exact sequence is proprietary)
- 亚型
- IgG1
- Top Product
- Discover our top product CDH16 Primary Antibody
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- 应用备注
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Positive Control: Normal kidney or renal cell carcinoma.
Known Application: ELISA (For coating, order Ab without BSA);Western Blot (2-4ug/ml);,Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 100 μg/mL
- 缓冲液
- Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
- 有效期
- 24 months
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- 抗原
- Cadherin-16 (CDH16)
- 别名
- CDH16 (CDH16 产品)
- 别名
- cadherin 16 antibody, CDH16 antibody, Cdh16 antibody
- 背景
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Cadherin-16 (CDH16), Kidney-specific cadherin, Ksp-cadherin antibody,Ksp-Cadherin/ CDH16 (Renal Cell Marker)
Cellular localisation: Cell Surface andCytoplasmic - 分子量
- 130kDa
- 基因ID
- 1014, 513660
- UniProt
- O75309
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