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- 抗原 See all MICA 抗体
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
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抗原表位
- AA 1-200
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MICA antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- MICA and MICB are stress-induced antigens that are related to major histocompatibility complex (MHC) class I molecules. MICA and MICB are frequently expressed in epithelial tumors. These highly glycosylated cell surface proteins are stably expressed without conventional class I peptide ligands or association with i²-2-microglobulin. The expression is induced on proliferating or heat shock-stressed epithelial cells. MICA and MICB are broadly recognized by intestinal epithelial V L1 i³ L T cells expressing variable TCRs, suggesting that these antigens may play a central role in the signaling of cellular distress to evoke immune responses in the intestinal epithelium.
- 交叉反应 （详细）
- Human, Mouse and Rat.
- 纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
- 免疫原
- Recombinant fragment (around aa1-200) of human MICA (exact sequence is proprietary)
- 亚型
- IgG2b
- Top Product
- Discover our top product MICA Primary Antibody
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anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 68-97) antibody
MICA 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB21777 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 120-170) antibodyMICA 适用: 人 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人 WB, FACS, IP 宿主: 小鼠 Monoclonal MEM-147 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro), CyTOF 宿主: 小鼠 Monoclonal W6-32 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro), Func, CyTOF 宿主: 小鼠 Monoclonal W6-32 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (FITC)MICA 适用: 人, Cow, Cat, Non-Human Primate FACS 宿主: 小鼠 Monoclonal W6-32 FITC
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (Biotin)MICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro) 宿主: 小鼠 Monoclonal W6-32 Biotin
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (PE)MICA 适用: 人, Cow, Cat, Non-Human Primate FACS 宿主: 小鼠 Monoclonal W6-32 PE
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (PE)MICA 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-147 PE
anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 24-307) antibodyMICA 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Positive Control: HeLa or MCF-7 cells. Human breast, kidney or prostate.
Known Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
- 有效期
- 24 months
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- 抗原
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
- 别名
- MICA (MICA 产品)
- 别名
- MIC-A antibody, PERB11.1 antibody, MHC class I polypeptide-related sequence A antibody, MICA antibody
- 背景
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HLA class I antigen, MHC class I chain related gene A protein antibody, MHC class I chain related protein A, MHC class I chain related protein A HLA B HLA C, MHC class I polypeptide related sequence A, MHC class I polypeptide-related sequence A, MHC class I related protein, MIC A, MIC-A, micA, PERB11.1, Stress inducible class I homolog,MICA
Cellular localisation: Cell surface. Cytoplasm. - 分子量
- 92kDa
- 基因ID
- 100507436
- UniProt
- Q29983
- 途径
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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